Shantha Biotechnics Limited manufactures R-DNA Hepatitis B Vaccine. Shantha Biotechnics Limited offers recombinant DNA vaccines and human healthcare products. The R-DNA Hepatitis B Vaccine, under the brand name Shanvac-B is recombinant vaccine and is produced in the yeast Pichia pastoris. Hepatitis B vaccine is used for the prevention of the deadly liver infection Hepatitis B which can lead to liver failure or cancer. The R-DNA Hepatitis B Vaccine is WHO-Geneva pre-qualified Hepatitis-B vaccine.